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Use of Goose Isolate of APV as a Vaccine for Turkeys

Avian - 2003

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The Problem

Four APV strains have recently been isolated from a group of Canadian geese capture in Minnesota. Preliminary data suggest that one of these is only mildly pathogenic to susceptible turkeys while confering a strong and protective immune response. Because the APV strains responsible for the disease in the U.S. all have significant homogeneity in surface antigenic genes, it is thought that an effective vaccine capable of providing protective immunity to commercial turkeys might be developed from this goose derived strain.

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Background

A summary of Avian Respiratory Disease Research Progress (1998-2001) is available. See also the project topic page for 2002.

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Objectives

This project specifically aims to:

• determine the genetic comparison of one specific Canadiangoose derived APV strain and test its safety and efficacy as a vaccine.
• determining whether the identified goose APV confers protection to turkeys from natural APV infections, and what route of administration (intranasal, cloacal, subcutaneous, or aerosolation) is most effective.
• field test the identified APV goose virus as a vaccine.

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